What is it?

GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. It is present in human plasma, saliva, and urine, although its natural concentration generally declines with age.

How does it work?

GHK-Cu transports copper and influences biological processes involved in tissue remodelling. Laboratory and topical research suggests it may stimulate collagen, elastin, and glycosaminoglycan production while supporting antioxidant activity, blood-vessel formation, and wound repair.

What is it good for?

Potential or commonly studied applications include:

• Improving the appearance of fine lines, firmness, and skin texture in topical formulations.
• Supporting wound healing and skin regeneration.
• Reducing the appearance of photodamage and certain types of scarring.
• Investigating hair-follicle support and healthier-looking hair, although clinical evidence is limited.

Summary (Pros and Cons)

Pros: Naturally occurring and widely used in topical skincare; promising evidence for skin repair, collagen support, and cosmetic rejuvenation.

Cons: Results vary among formulations, and evidence for hair restoration or systemic use is limited. Injectable GHK-Cu lacks well-established safety, dosing, and long-term efficacy data.

General Overview

GHK-Cu is one of the more established cosmetic peptides, particularly in topical skin-repair and anti-ageing formulations. Its strongest practical role is in skincare; broader claims involving systemic rejuvenation or significant hair regrowth require better-quality human trials.